Dr. Adam Grieve

Upon completing my doctoral studies at UCL, London with Dr. Tim Levine, I joined the group of Prof. Catherine Rabouille at the Hubrecht Institute, the Netherlands where my interest in proteolysis began. After four years, I returned to the UK where I am currently working with Prof. Matthew Freeman. My primary line of research is membrane trafficking and proteolysis, with a focus on how these often intersecting processes regulate events such as intercellular signalling and cell-cell adhesion. These processes control normal physiology but often go awry in disease. My work has revealed the cellular consequences of E-cadherin cleavage in epithelia, and also cell biological mechanisms that regulate the activity of the metalloprotease, TACE. Currently, my major focus is the discovery of novel substrates for the rhomboid family of intramembrane proteases, which, in combination with studies with mammalian model systems, will reveal their physiological roles.