Selected publications

Düsterhöft S., Künzel U., Freeman M. (2017). Rhomboid proteases in human disease: Mechanisms and future prospects. Biochim Biophys Acta.

Grieve A.G., Xu H., Künzel U., Bambrough P., Sieber B., Freeman M. (2017). Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling. Elife  DOI: http://dx.doi.org/10.7554/eLife.23968.001

Lastun V.L., Grieve A.G., Freeman M. (2016). Substrates and physiological functions of secretase rhomboid proteases. Semin Cell Dev Biol 60, 10-18.

Siggs O.M., Grieve A., Xu H., Bambrough P., Christova Y., Freeman M. (2014). Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice. Biol Open 3, 1151-1157.

Christova Y., Adrain C., Bambrough P., Ibrahim A. and Freeman M. (2013). Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation. EMBO Rep 14, 884-890.

Vinothkumar K. R., Pierrat O. A., Large J. M. and Freeman M (2013). Structure of rhomboid protease in complex with beta-lactam inhibitors defines the S2’ cavity. Structure 21, 1051-1058.

Adrain C and Freeman M. (2012). New lives for old: evolution of pseudoenzyme function illustrated by iRhoms. Nat Rev Mol Cell Biol 13,489-498.

Adrain C., Zettl M., Christova Y., Taylor N. and Freeman M. (2012). TNF signalling requires iRhom2 to promote trafficking and activation of TACE. Science, 335, 225-8.

Zettl M., Adrain C., Strisovsky K., Lastun V., and Freeman M. (2011). Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling. Cell 145, 79-91.

Adrain C., Strisovsky K., Zettl M., Hu L., Lemberg M. K., and Freeman M. (2011). Mammalian EGF receptor activation by the rhomboid protease RHBDL2. EMBO Rep. 12, 421-427.

Pierrat O. A., Strisovsky K., Christova Y., Large J., Ansell K., Bouloc N., Smiljanic E., and Freeman M. (2011). Monocyclic beta-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases. ACS Chem Biol 6, 325-335.

Vinothkumar K. R., Strisovsky K., Andreeva A., Christova Y., Verhelst S., and Freeman M. (2010). The structural basis for catalysis and substrate specificity of a rhomboid protease. EMBO J. 29, 3797-3809.

Strisovsky K., Sharpe H., and Freeman M. (2009). Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates. Molecular Cell 36, 1048-1059.

Freeman M. (2008). Rhomboid proteases and their biological functions. Annu Rev Genet 42, 191-210.

Lemberg M. K., and Freeman M. (2007). Cutting Proteins within Lipid Bilayers: Rhomboid Structure and Mechanism. Molecular Cell 28, 930-940.

Stevenson L.G., Strisovsky K., Clemmer K.M., Bhatt S., Freeman M., Rather P.N. (2007). The rhomboid protease AarA mediates quorum sensing in Providencia stuartii by activating TatA of the twin-arginine translocase. Proc Natl Acad Sci U S A 104, 1003-1008.

Lemberg M.K., Menendez J., Misik J., Garcia M., Koth C.M. and Freeman M. (2005). Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases. EMBO J., 24, 464-472.

McQuibban G.A., Saurya S. and Freeman M. (2003). Mitochondrial membrane remodelling regulated by a conserved rhomboid protease. Nature, 423, 537-541.

Urban S., Lee J.R. and Freeman M. (2001). Drosophila Rhomboid-1 defines a novel family of putative intramembrane serine proteases. Cell 107, 173-182.

Lee J.R., Urban, S., Garvey C.F. and Freeman M. (2001). Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila. Cell 107, 161-171.

Freeman M. (2000). Feedback control of developmental signalling. Nature, 408, 313-319.

Wasserman J.D., Urban S. and Freeman M. (2000). A family of rhomboid-like genes: Drosophila rhomboid-1 and rhomboid-3 cooperate to activate EGF receptor signalling in the eye. Genes and Development, 14, 1651-1663.

Casci T., Vinós J. and Freeman M. (1999). Sprouty, an intracellular inhibitor of Ras signalling. Cell, 96, 655-665.

Wasserman J.D. and Freeman M. (1998). An autoregulatory cascade of EGF receptor signalling patterns the Drosophila egg. Cell, 95, 355-364.

Freeman M. (1996). Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell, 87, 651-660.

Schweitzer R., Howes R., Smith R., Shilo B., and Freeman, M. (1995). Inhibition of Drosophila EGF receptor activation by the secreted protein Argos. Nature, 376, 699-702